Singular Value Decomposition–Based Alternative Splicing Detection
نویسندگان
چکیده
منابع مشابه
Role of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Splicing and alternative splicing are major processes in the interpretation and expression of genetic information for metazoan organisms. The study of splicing is moving from focused attention on the regulatory mechanisms of a selected set of paradigmatic alternative splicing events to questions of global integration of splicing regulation with genome and cell function. For this reason, paralle...
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MOTIVATION Transcripts from approximately 95% of human multi-exon genes are subject to alternative splicing (AS). The growing interest in AS is propelled by its prominent contribution to transcriptome and proteome complexity and the role of aberrant AS in numerous diseases. Recent technological advances enable thousands of exons to be simultaneously profiled across diverse cell types and cellul...
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در این پایان نامه به معرفی روشهای مختلف محاسبه psvd می پردازیم. بخشی از این روشها به بررسی روشهای مختلف محاسبه psvd در مقالات مطالعه شده می پردازد که می توان به محاسبهpsvd با استفاده از الگوریتمهای pqrd و pevd و sbr2 و محاسبه psvd براساس تکنیک kogbetliantz و روش پارامتریک برای محاسبه psvd اشاره نمود. بخش بعدی نیز به بررسی روشهای مستقیم پیشنهادی محاسبه psvd برای ماتریسهای 2×2و2× n و n×2 و 3× n و...
15 صفحه اولDetection and prediction of alternative splicing in Arabidopsis thaliana
Alternative splicing is an important process for increasing the diversity arising from a single gene. Presently, most studies aimed at detecting alternatively spliced genes use Expressed Sequence Tags (ESTs). However, the EST studies based on spliced transcripts analyse sequences by alignment rather than sequence patterns. Second, EST libraries can be of uncertain quality. To address these issu...
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ژورنال
عنوان ژورنال: Journal of the American Statistical Association
سال: 2009
ISSN: 0162-1459,1537-274X
DOI: 10.1198/jasa.2009.ap08283